CellScale Blog

Tissue spheroids are a growing pre-clinical tool for drug development. Succeeding in this application will require quality, repeatability, and standardization. The MicroTester is perfectly suited for mechanical compression of tissue spheroids. In a recent paper Elena...

Dr. Xuanhe Zhao from MIT and his global team present an effective and strong solution to bond wet conducting polymers on diverse substrates. This adhesive layer can be applied on by spin-coating, spray-coating or dip-coating. Read on for more details of the fabrication and electrical and mechanical tests.

Dr. Kam Chiu Tam and his team at the University of Waterloo proposes a solution for heavy metal pollution in wastewater. Their modified cellulose aerogel beads were shown to exhibit high copper absorption capacity and rate, high shape recovery and robust mechanical strength. Best of all, they could be regenerated and reused.

Dr. Andreas Nüssler and his team from Eberhard Karls University have developed scaffolds that mimic the rigidity of healthy and fibrotic liver tissue. Thereafter they studied the metabolic activity of liver cells on these scaffolds. Read more about how this research impacts the movement for drug testing in non-animal models.

Dr. Elena Bulanova and her team at the Laboratory for Biotechnological Research 3D Bioprinting Solutions in Russia present their article on fabrication and analysis of tissue spheroids. Their design protocol applies to any cell line and aims to meet high quality standards such as consistent geometry, defined mechanical properties and viability.

Dr. Li Liu and her team at the Osaka University Graduate School of Medicine present their breakthrough research to mature hiPSC-derived cardiomyocytes in a self-organized tissue ring. By mimicking the physiology of adult cardiomyocytes, the team’s findings present a viable solution to drug screening and regenerative therapy applications.

Dr. Ali Tamayol and his team from the University of Nebraska-Lincoln developed a wearable device that can deliver agents to critical layers of the wound bed in a minimally invasive fashion. Read more about their solution to treat chronic wounds suffered by diabetic patients.

Dr. Jon Pokorski and his team from the University of California at San Diego presents a solution to high-cost, bulky and high-material-consuming melt-processing system for academic laboratories. In his study, he demonstrates the dispersion of particles in melt processed polymers produced by their invention.

Dr. Carlijn V.C. Bouten and her team at the Eindhoven University of Technology explored into the underlying mechanisms of premature graft failure by creating a human in vitro model of material-driven vascular regeneration. Read on to discover how cyclic stretch and shear stretch respectively affects inflammation and tissue formation.

Dr. Georgina Carbajal de la Torre and her team from Universidad Michoacana de San Nicolas de Hidalgo in Mexico shares with us her fascinating research into various synthetic mesh for abdominal wall hernia repair. By understanding the mechanical properties of these materials, surgical treatments of abdominal hernia can vastly improve thus reducing the hernia recurrence rate for patients.

Ludovica Cacopardo from the University of Pisa under Associate Professor Arti Ahluwalia publishes this article on a new testing method for viscoelasticity through stress-rate measurements and load-control testing. Learn how the MechanoCulture TR played a major role in their discovery.

Here is the first customer publication highlight featuring a commercial (non-academic) entity and their research with our equipment! Dr. Desmond Adler and his team from Avedro (now a Glaukos company) investigated on the optimization of oxygen dynamics, UV-A delivery, and drug formulation for Accelerated Epi-On Corneal Crosslinking.

University of Arizona’s Dr. Jeong-Yeol Yoon and his Ph.D. student Kattika Kaarj presents this journal paper on Organ-on-a-chip devices and the mechanical stimuli they can create on human cells and tissues. This excellent summary focuses on the technical details of device design and equipment used, categorizing them under 5 types of mechanical stimuli.