High throughput uniaxial stimulation of cell cultures with real-time imaging.
The MCFX uses a single-use flexible silicone well plate to culture cells in much the same environment as a traditional polystyrene well plate. After allowing the cells to develop adhesion to the well bottom, the MCFX can execute a user-specified stretch protocol to the well plate, causing the cells to deform. The well bottoms have similar optical properties to a glass coverslip, permitting high-magnification imaging of the cultured cells. The well plates can be sterilized and the system is suitable for long-term cell culture in a laboratory incubator.
- Uniaxial stretch of 16 culture wells in a single-use silicone well plate
- 0.4mm thick membranes for high-magnification imaging using an inverted microscope
- PC-independent operation
- User-friendly interface software for specifying simple, cyclic, and intermittent stimulation protocols for download to the device controller
Adhered Cell Monolayer Culture
Single-use silicone well plate. Cell culture wells are 8mm X 8mm with a 0.4mm thick transparent bottom membrane. The 16 cell culture surfaces are shown in red.
We are using CellScale equipment for the last two years to assess the influence of mechanical stimulation on permanently differentiated and stem cells' fate. The interface is user-friendly, the customer support service is very helpful, the equipment is easy to use and inexpensive, yet precise and robust.
The CellScale MechanoCulture has been a very versatile bioreactor platform for us. It's size and the ability to pre-program the bioreactor conditions results in a cost-effective solution to our bioreactor needs. In addition, the software is intuitive and easy to use. CellScale has been easy to work with and has quickly addressed any issues we have come across.
|Dimensions||19 X 9 X 10cm|
|Stimulation mode||Uniaxial tension|
|Culture area||16 wells, 8mm X 8mm|
|Maximum Cycle Frequency||5Hz|